Why is the protein scaffold so strong?
Why is it so strong that it can be used to build protein scaffolds?
And how do scaffolds make the scaffold look like a protein scaffolding?
A team of researchers from the University of Western Australia (UWA) and the University, New South Wales, has developed a protein-scaffolding scaffold made from a biomimetic scaffold that they hope will be able to be used in the construction of new proteins.
The scaffold consists of a flexible polymer called p-hydroxyacetate (pHA), a peptide hydroxylase (PH), and an acetyl group attached to a hydroxynonenal hydroxide (HNE) substrate.
The PH molecule is an enzyme that is used to break down the hydroxymethyl group of the HNE, which is essential for the polymer to form the protein.
In the case of the protein, the pHA molecule has been used to form a scaffold to allow the PH molecule to be incorporated into the scaffolding.
The researchers say the structure allows the scaffolded protein to be formed without the need for any other form of scaffolding, which means the scaffolds can be manufactured much faster.
“The scaffolds have been created using biomimicry technology that was developed at the University,” said Professor Brian Jones, a researcher at the UWA’s School of Chemistry and Biochemistry.
“We think the structure has some very interesting properties, and it may be used for many other purposes, including the creation of new biomimetics, structural proteins and other biomimics.”
The researchers said the protein can be formed from a single-stranded DNA strand and then can be folded into various shapes, which could be used as scaffolds for proteins, molecules, or other biomaterials.
The protein scaffhold can be made of a variety of substrates including a cellulose, polyethylene or polypropylene polymer, cellulose-coated polyvinylidene fluoride (PVCPF), and other materials, but the researchers said they had the ability to manufacture it with the most efficient biomimicking materials.
“This is an exciting breakthrough,” said Prof Jones.
“For the first time, we have created a scaffolding that does not require any specific structure to form and can be produced from biomimically formed protein scaffolded by any of these substrates.”
It is extremely promising because it shows us that we can make biomimetically produced protein scaffrews.
“In addition to the structure, the team has demonstrated the structure can be constructed from several different types of substrases, including polyvinylene-polypropylene (PVPP), polypropyleneglycol (PPEG), polyglycerol (PG), and cellulose.”
With these new technologies, we are working towards the development of the next generation of biomimical protein scaffrows,” said Dr David Brouwer, one of the lead researchers on the project.”
Our research team is excited by the potential of these materials and are hopeful that they can be incorporated to create the next step in the manufacturing of biomaterial scaffolds.